Abstract
It is well accepted that the main route of the SARS-CoV-2 entry to the body is via respiratory epithelial cells. However, skin cells also express ACE2 and TMPRSS2, the major factors that control SARS-CoV-2 host cell entrance. The dermatological lesions including chilblain-like acral lesions (COVID toes), vasculitis-like, urticaria-like lesions and maculopapular eruptions were reported in 1%–20% of COVID-19 patients, and SARS CoV-2 RNA was detected in skin biopsy and autopsy of some of COVID-19 patients.
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