Abstract
Background: Neonatal sepsis is a disease with a high impact on endothelium dysfunction, resulting in an impairment of microcirculation. The first clinical signs may be feeding intolerance and a prominent abdomen with palpable bowl, suggesting that the intestinal microcirculation is a location, where early endothelium response of the neonatal organism can be observed. As of today evaluation of the neonatal microcirculation ist still a challenge, intravital microscopy (Orthogonal Polarization Spectral-Imaging) seems to be a promising new approach. Protein C, the zymogen of vitamin K dependent serine protease activated Protein C plays a pivotal role in regulation of microvascular coagulation and inflammation. Mortality in septic patients can be decreased by the use of Protein C. However, the direct impact of Protein C on the microvascular blood flow has not been investigated, yet.
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