84P Predicting longer-term progression-free survival (PFS) with durvalumab after chemoradiotherapy (CRT) in unresectable stage III NSCLC using a mixture cure model (MCM)

Abstract

Five-year results from the placebo-controlled phase 3 PACIFIC trial (NCT02125461) demonstrated robust and sustained overall survival (OS) and durable PFS benefit with durvalumab (given every 2 weeks up to 12 months) in pts with unresectable Stage III non-small-cell lung cancer (NSCLC) and no disease progression after platinum-based concurrent CRT. Given the potential for longer-term PFS gain in this curative-intent setting, we used MCM analysis, a common statistical model in such settings, to predict the potential longer-term PFS benefit with durvalumab.