846: Prenatal exposure to preeclampsia and long- term ophthalmic morbidity of the offspring

Abstract

Preeclampsia is a multisystem progressive disorder characterized by hypertension and significant end-organ dysfunction including maternal ophthalmic involvement. The aim of this population-based study was to examine whether exposure to preeclampsia poses a risk for long-term ophthalmic morbidity of their offsprings. A population-based cohort analysis compared the incidence of long-term ophthalmic morbidity in children prenatally exposed and unexposed to preeclampsia. All infants were born between the years 1991-2014 at a single tertiary medical center. A Kaplan-Meier survival curve was conducted to compare cumulative hospitalization incidence between the groups. A Cox regression model was used to control for confounders. During the study period, 242,342 births met the inclusion criteria. Of them, 7,279 (3.0%) of the deliveries were to mothers diagnosed with mild preeclampsia and 2,222 (0.95%) with severe preeclampsia or eclampsia. The cumulative incidence of ophthalmic morbidity was significantly higher in children delivered following severe vs. mild preeclampsia (Figure, Kaplan-Meier survival curve log-rank P=0.039). However, using a Cox regression model to control for confounders, such as maternal age and gestational age, no association was found between preeclampsia and long-term risk for ophthalmic morbidity of the offspring (mild preeclampsia; adjusted HR 0.807, 95% CI 0.626-1.041, severe preeclampsia; adjusted HR 1.098, 95% CI 0.759-1.587; Table). The cumulative incidence of ophthalmic morbidity is higher in children delivered following severe vs. mild preeclampsia. Nevertheless, in our population, prenatal exposure to preeclampsia was not found to be an independent risk factor for long-term ophthalmic morbidity of the offspring.View Large Image Figure ViewerDownload Hi-res image Download (PPT)