Abstract
Objectives. Adenovirus is a useful vector for cancer gene delivery because of its high gene transfer efficacy, high titer production, and safety. The initial binding of adenoviruses except for serotype B to cell surface is mediated via a specific 46 kDa coxsackie and adenovirus receptor (CAR). In addition, recent evidence suggested that CD46, a complement inhibitory protein, plays a role as a serotype B Ad receptor. Low levels of CAR are associated with decreased efficiency of adenovirus-mediated gene transduction of bladder cancer. In present study, we evaluated the expression of CAR and CD46 in urologic cancer cell lines, and then examined whether CAR expression is associated with bladder cancer characteristics and clinical outcomes.
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