Abstract
Delivery of antigens to dendritic cells (DCs) plays a pivotal role in the induction of efficient immune responses ranging from immunity to tolerance. A potent antigen specific T-cell response directed against multiple epitopes was induced by recombinant viruses. As a prerequisite for such an application, the infection of DCs by recombinant viruses should not interfere with their stimulatory capacity. The murine parainfluenza virus type I or Sendai virus (SeV) has emerged to a prototype virus of a new class of negative-strand RNA virus vectors, being employed in numerous in vitro as well as preclinical and clinical studies over the last few years.
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