Abstract
Interferon regulatory factor-1 (IRF-1) is a transcription factor involved in the inflammatory response following hepatic ischemia/reperfusion (I/R) injury. The specific cell type within the liver, parenchymal (hepatocyte) versus non-parenchymal (kupffer cell, dendritic cell, etc), in which IRF-1 activation occurs is unknown as are the signals responsible for its upregulation. We hypothesized that hepatic non-parechymal cells (NPCs) are stimulated during I/R to release factors that activate hepatocellular IRF-1 and thus lead to liver damage.
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