Abstract
Patients with advanced ovarian clear-cell carcinoma (OCC) have poor prognosis in the absence of an effective standard treatment. The response rate of chemotherapy for relapsed OCC is <10%. Gemcitabine and cisplatin are reported to have a synergic effect on ovarian cancer. Evidence indicates that addition of bevacizumab to a chemotherapy regimen improves progression-free survival. We conducted a multi institutional phase II trial in Japan to examine the efficacy and safety of a gemcitabine, cisplatin, and bevacizumab combination (GPB) therapy for OCC.
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