Abstract
Background: Kidney function is not typically assessed in PNI research even though impaired clearance is associated with poor health and hypertension, and inflammatory conditions affect renal physiology. The goal of this study was to determine if glomerular filtration rate (GFR) was associated with aging, interleukin-6, and cell adhesion markers in older adults. Methods: GFR was estimated from creatinine clearance adjusted for body surface area in 1255 Americans from the MIDUS II project. Results. Older age was associated with reduced GFR, r = −.38, p < .01, and increased IL-6, r = .13, p < .01. After controlling for age, reduced GFR was associated with higher IL-6, r = −.09, p < .01, higher C-reactive protein, r = −.05, p < .05, higher fibrinogen, r = −.03, p < .05 and reduced serum E-selectin, r = .06, p < .05. However, soluble ICAM-1 was not significantly associated with GFR after controlling for age. Conclusions. These findings document the GFR declines in association with rising IL-6, CRP and FBG in many older adults. We did not replicate previous reports of a correlation between GFR and sICAM-1 found in dialysis patients. Nevertheless, these linkages between GFR and 3 biomarkers are reflective of a subclinical proinflammatory state and indicate it is important to pay attention to kidney function when investigating the immunobiology of aging.
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