82P Exploring the prognostic role of DNA damage sensing deficiency for immune checkpoint blockade in diverse cancer types

Abstract

Immune checkpoint blockade (ICB) produces durable responses on difficult-to-treat tumors, but its effects are heterogeneous on patients. DNA damage response (DDR) is a network of multiple functional pathways to maintain genomic stability, and mutations in DDR genes are a major determinant of response to ICB. However, only a subset of DDR-altered patients benefit from ICB, and their responses vary across cancer types.