Abstract
Vibrational circular dichroism (VCD) is the extension of electronic CD into infrared and near-infrared regions where vibrational transitions occur. VCD is one of the two principal areas of vibrational optical activity, the other being vibrational Raman optical activity. Experimental and theoretical methodologies are presented as a basis for measuring and calculating VCD spectra. Instrumentation and computational advances are explained as a guide for carrying out applications of VCD, these being absolute configuration determination, enantiomeric excess determinations, reaction monitor of multiple chiral species, conformational analysis of biological molecules including amyloid fibrils and VCD of solids with extensions for raw-material identification, and formulated drug analysis in the pharmaceutical industry. With these current and projected applications, VCD is realizing its potential as a powerful new stereochemical tool for chiral structure elucidation.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
