Abstract
The optimal timing of pregnancy following bariatric surgery has not been established, with data limited regarding laparoscopic sleeve gastrectomy (LSG). We aimed to explore associations of the surgery-to-conception interval with pregnancy outcomes after LSG. We assessed pregnancy outcomes in relation to the surgery-to-conception interval for all women who underwent LSG and delivered during 2006-2018 in a university hospital. Of 154 patients, 67 (43.5%) conceived within the first 18 months postoperatively (early pregnancy group), whereas 87 (56.5%) conceived later (late pregnancy group). The median surgery-to-conception interval was 699 [interquartile range 423-1188] days. Baseline characteristics were comparable between the groups. Compared to the early pregnancy group, for the late pregnancy group, gestational weight gain was higher (median 11 vs. 8 kg, P<0.001), and hemoglobin levels were lower in early pregnancy (P=0.03) and after delivery (P=0.02). Other maternal and perinatal outcomes were similar between the groups, including the proportions of low-birth weight (7.5 vs. 11.5%, P=0.58) and small-for-gestational-age (SGA) infants (11.9% vs. 14.9%, P=0.64) for those who conceived within or later than 18 months after surgery. The delivery of a SGA infant was not found to associate with any of the patient characteristics assessed, including the surgery-to-conception time interval (P=0.30) and gestational weight gain (P=0.14). Timing of pregnancy after LSG was found not to be associated with pregnancy outcomes. Together with documentations of a similar safety profile of pregnancy occurring earlier or later in the postoperative course, these data should reassure women who wish not to delay conception following surgery.
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