821 The -109C>T Polymorphism of the Fcer1B Gene in Children with Asthma

Abstract

Among the genes predisposing individuals to atopy, several variants of the FCER1B gene were reported to associate with atopic asthma. One of them, a substitution of cytosine to thymine at position 109 in promoter region of the FCER1B gene has been shown to be associated with total IgE levels. The aim: To investigate genotype and allele distribution of the FCER1B gene polymorphism in children with asthma. Study groups: Children with mild asthma (72 boys and 10 girls), children with severe asthma (42 boys and 16 girls) aged 3 -17 years old. Controls: 136 healthy children (65 boys and 71 girls) aged 4-17 years old. The -109C>T polymorphism was identified by PCR-RFLP. The data was compared with Chi-square test. Results: Genotype and allele distribution in asthmatic subjects and controls are presented in the table 1. Conclusion: There were no significant differences in genotype and allele distribution in affected children according to their sex and severity of the disease. Both allele and genotype distribution of the FCER1Bgene polymorphism were similar in asthmatic subjects and in controls, being in line with previously reported data.