Abstract
protracted”in at least two biopsies). The presence of C4d however has no significant influence on long term survival. Increase of NTproBNP and hs CRP levels were independently correlated with poor long term outcome in pts after OHT in multivariate Cox analysis. The cut off values determined by AUC analyses for NTproBNP were 5141 pg/ml and hsCRP> 0,698 mg/dl. Pts with higher levels of NtproBNP or hsCRP had significantly shorter survival (log rank respectively p< 0.0001 and p< 0.0002). Conclusion: 1. Averaged increased post transplantation serum levels of NTproBNP and hs CRP are independent markers of long term worsened survival of pts after heart transplantation. 2. C4d deposition in myocardial capillaries in myocardial biopsies is of limited prognostic value.
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