Abstract
The search for anticancer therapy targets is the main task of oncology. One hopeful target is a membrane glycoprotein the sodium-dependent phosphate transporter NaPi2b overexpressed in ovarian carcinomas. NaPi2b is an antigen for the MX35 antibody which recognizes an epitope in the large extracellular domain (ECD) of the NaPi2b mostly in tumor but not in normal cells. The ECD contains 4 cysteines at positions 303, 322, 328, 350 and potential N-glycosylation sites at positions 295, 308, 313, 321, 335, 340.
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