Abstract
Diet and microbiome are intricately linked to mucosal gut immunity and the systemic immune response, yet their connection to inflammatory skin diseases, such as psoriatic dermatitis (PsD), has yet to be elucidated. Recent studies have shown bile acids (BA)s are involved in dampening systemic Th17 pathway activity and improving Th17-induced ulcerative colitis. We investigated into whether BA supplementation could downregulate the Th17 response and improve PsD in mice. We fed mice a western diet (WD) to induce PsD, with and without the BAs lithocholic acid (LCA) and deoxycholic acid (DCA).
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