Abstract
Chronic pain can cause problems with sleep, such as difficulty initiating and maintaining sleep. A potential benefit of opioid therapy is minimizing sleep problems by reducing pain. A 6-week, open-label, randomized, comparative, repeated-dose, parallel-group study was performed to characterize the efficacy, safety, and quality-of-life impact of once-daily OROS® hydromorphone and twice-daily ER oxycodone in 126 patients with chronic osteoarthritis (OA) pain of the knee or hip. All participants had been receiving long-term treatment with NSAIDs or another non-steroidal, non-opiod analgesic.
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