Abstract
Protein phosphatase 2A (PP2A) is a critical target to control cumulative oxidative stress and chronic inflammation during skin aging by reversible methylation of the C-terminal leucine of the PP2A catalytic subunit (PP2Ac). A novel, proprietary Activated-Grape Seed Extract (AGSE), enriched for PP2A-activating flavonoids, was recently developed, and has demonstrated potent antioxidant and anti-inflammatory activities. AGSE is a dark, purple-colored powder with limited solubility, which restricts its use in a broad range of formulations.
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