815P - Prognostic value of systemic inflammatory biomarkers in patients with mCRPC treated with abiraterone in pre-docetaxel setting

Abstract

Background: Systemic inflammatory biomarkers have shown a prognostic impact in several solid tumors. The aim of this study was to examine the prognostic role of baseline neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR) and lymphocyte-to-monocyte-ratio (LMR) and NLR, PLR and LMR changes at 1, 2 and 3 months in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) treated with Abiraterone Acetate (AA) in pre-docetaxel setting. Methods: We retrospectively included mCRPC pts treated with AA at two Italian hospitals from November 2012 to April 2017. NLR, PLR and LMR were evaluated at baseline and after 1, 2 and 3 months of treatment. The impact of NLR, PLR and LMR on progression-free survival (PFS) was evaluated by Cox regression analyses both in univariate and multivariate fashion. Other clinico-pathological factors, such as PSA baseline level, Time to CRPC, Gleason Score, Presence of Visceral Metastases and Bone Metastases Burden were included. Results: Fifty mCRPC pts treated with AA were evaluated. At univariate analysis, elevated baseline NLR and PLR were significantly associated with shorter median PFS (p = 0.01, hazard ratio [HR]=1.224 and p = 0.0001, HR = 1.013 respectively); after 1 month of treatment, NLR and PLR were significantly predictors of worst PFS (p = 0.03, HR = 1.320 and p = 0.02, HR = 1.012 respectively). After 2 and 3 months of treatment, only high PLR was associated with poor prognosis (p = 0.01, HR = 1.012 at month 2; p = 0.009, HR = 1.009 at month 3 respectively). LMR didn’t show any prognostic relevance. At multivariate analysis, only baseline PLR was independently associated with PFS (p = 0.006, HR = 1.013). Conclusions: High baseline and early-assessed NLR and PLR during treatment with AA are associated with shorter PFS in mCRPC pts. PLR more than NLR may be considered as an early and easy-to-perform prognostic marker in this setting. Legal entity responsible for the study: Fondazione IRCCS Istituto Nazionale dei Tumori of Milan Funding: None Disclosure: E. Verzoni: Advisory boards: Jannsen. G. Procopio: Advisory board: Astellas, Bayer, Janssen and Roche. All other authors have declared no conflicts of interest.