Abstract
The HER2 receptor plays an important role in the aberrant proliferation of cancer cells with modification of the cell cycle profile. Phosphorylation of HER2 (pHER2) which represents the functional and active form of HER2 is a precondition for downstream signalling network involved in cell growth, invasion and metastasis. The aim of our study was to investigate the HER2 protein expression in both primary tumors and paired regional lymph nodes in relation to cell cycle profile in bladder cancer.
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