809 TESTOSTERONE DEFICIENCY IS A POSSIBLE RISK FACTOR FOR PRIAPISM ASSOCIATED WITH SICKLE CELL DISEASE

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research I1 Apr 2012809 TESTOSTERONE DEFICIENCY IS A POSSIBLE RISK FACTOR FOR PRIAPISM ASSOCIATED WITH SICKLE CELL DISEASE Belinda Morrison, Marvin Reid, Wendy Madden, Zhaoyong Feng, and Arthur Burnett Belinda MorrisonBelinda Morrison Kingston 7, Jamaica More articles by this author , Marvin ReidMarvin Reid Kingston 7, Jamaica More articles by this author , Wendy MaddenWendy Madden Kingston, Jamaica More articles by this author , Zhaoyong FengZhaoyong Feng Baltimore, MD More articles by this author , and Arthur BurnettArthur Burnett Baltimore, MD More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.898AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Priapism has a high incidence in sickle cell disease (SCD). Testosterone deficiency has been recognized in adolescent and adult males with SCD. We sought to determine the association of testosterone deficiency and priapism in adult men with SCD. METHODS A cross-sectional study of 50 adult men with homozygous S SCD was performed. All patients had early morning blood taken for total and free testosterone, FSH, LH, prolactin, lipid levels, LDH and hematological indices. Patients completed an interviewer administered questionnaire regarding priapism frequency, duration and treatment. Hypogonadism was defined as serum total testosterone < 12 nmol/L. The association of testosterone deficiency and priapism was determined. RESULTS Priapism was noted in 24 (48%) patients and was most frequently seen in men between ages 18-25 years. Mean age of the study population was 34.2 ± 8.9 years, and there was no difference in age based on history of priapism. Hypogonadism was assessed in 6 of 24 (25%) patients with priapism. There was no difference in mean total testosterone levels in patients with and without a history of priapism (16.7± 4.9 nmol/L and 15.4±5.9 nmol/L, respectively). Similarly, there was no difference in serum LH and FSH levels based on history of priapism. Of the patients who reported a history of priapism, there was no difference in frequency, number and duration of priapism episodes relative to total or free testosterone levels. There was a trend towards an association of free testosterone levels (p = 0.09) and duration of priapism episodes >30 min (p=0.09). CONCLUSIONS Hypogonadism is prevalent in patients with SCD. There is a 25% risk association of hypogonadism and priapism. Prospectively gathered data is needed to define the priapism profile of SCD patients with hypogonadism. Table 1. Responses to priapism questionnaire in study patients Frequency (%) History of priapism 48 Age of onset of priapism (yrs) 13-17 36 18–25 59 >25 5 Precipitating activity Sleep 95 Intercourse 5 Frequency of priapism episodes Daily 9 Alternate days 14 Once weekly 18 Once monthly 14 Other 45 Duration of priapism episodes <30 min 41 1 hour 32 2 hours 9 2–5 hours 9 >5 hours 9 Table 2. Laboratory values of patients with priapism Variable (Normal range) Mean values in patients with priapism Mean values in patients without priapism Age (yrs) 32.6±1.7 35.8±1.7 Haemoglobin (Hb) (14.0-18.0 g/dl) 7.8±1.8 7.9±1.8 LH (0-25 IU/L) 7.4±2.3 8.1±2.4 FSH (0-20 IU/L) 7.2±4.6 7.2±4.8 Total Testosterone (12.5-38.1 nMol/L) 16.7±4.9 15.4±5.9 Free Testosterone (194.4-936.1 pMol/L) 327.0±135.3 287.8±108.0 © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e330-e331 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Belinda Morrison Kingston 7, Jamaica More articles by this author Marvin Reid Kingston 7, Jamaica More articles by this author Wendy Madden Kingston, Jamaica More articles by this author Zhaoyong Feng Baltimore, MD More articles by this author Arthur Burnett Baltimore, MD More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...