809 Ovarian cancer in Kazakhstan for 15 years (2005–2020)

Abstract

<h3>Introduction/Background*</h3> According to Globocan 2020, ovarian cancer (OC) is the 11th most common cancer among women worldwide. It is more than 320,000 new cases of OC were registered each year and more than 200,000 deaths worldwide in 2020. To date, there are no recommended methods for screening of OC. More than 70 per cent of OC is detected in the late stages. In Kazakhstan (KZ), OC is the 3rd most common gynaecological cancer with the one of highest mortality rate in women. The proportion of OC among all cancers was 2.9% in 2020. The purpose of this study was to analyse OC incidence, mortality and survival for 15 years (2005-2020) in KZ. <h3>Methodology</h3> Incidence data, mortality statistics were sourced from the cancer registry database. All incidence and mortality rates were directly age-standardised to the World Standard Population. Data on survival were obtained from specific reports. We used Kaplan-Meier method to estimate cumulative observed survival. The statistical processing was carried out with SPSS 23.0 for Windows <h3>Result(s)*</h3> In KZ 14.125 new cases of OC have been diagnosed from 2005 to 2020. In the analysis of Standardized Incidence of OC, there is a stable rate for 10 years: 9.8 per 100,000 female population in 2005 and 10.0 per 100,000 female population in 2020. OC is found in all age groups and a noticeable increase in a group of 65-69 years. In the analysis of OC by stages is marked a decrease in the detection rate of the disease at the 4th stage for the period from 2005 to 2020, from 20 to 8.8%. Despite this, mortality from OC for ten years remains stable high and it is 4.6 per 100,000 female population in 2020. It is 7.458 women with OC who died from 2005 to 2020. Five-year relative survival for all stages of OC estimates of 20.3% (95%CI: 18.7-21.1). <h3>Conclusion*</h3> Analysis of OC Incidence in KZ showed a stable rate. Despite the reduction in the detection of ovarian cancer at stage 4, mortality from this disease remains high. According to these results, Kazakhstan is among the counties with low five-year OC survival.