Abstract
Administration of Epinephrine (EPi) is an integral part of resuscitation of ventricular fibrillation (VF). The mechanism of its action is not known. To evaluate this, 20 open chested pigs were studied using Endocardial (EN) and Epicardial (EP) Monophasic Action potentials (MAP) recordings. Defibrillation is achieved by using two EP patch electrodes, Each animal is fibrillated by using AC current and allowed to fibrillate for 10 minutes, ECG, BP, RV, LV, EN, and EP MAPs were recorded every minute during VF and resuscitation. At 10’ of VF, each animal is randomized either to EPi or saline and cardiac massage was instituted for 5 minutes. The heart was then defibrillated. In both groups. cycle lengths of MAPs and synchronization of repolarization which is the interval between EN and EP MAPs were measured during VF and resuscitation. The results were 10/10 of EPi and 1/10 saline animals were resuscitated. Successful defibrillation with EPi is because of: 1) shortening of cycle length, and 2) synchronization of repolarization.
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