802 Impaired blood clearance of macromolecules in a porcine acute liver failure model, with or without treatment with molecular adsorbents recirculating system (MARS), suggesting functional absence of liver sinusoidal endothelial cells (LSEC)

Abstract

The relationship between post-prandial plasma glucose (PPG) and post-challenge plasma glucose (PCG) within individuals was investigated in Japanese population. The oral glucose tolerance test (OGTT) and measurements of PPG 2 h after ingestion of a standardized rice-based meal (PPG2h), were performed in 4471 middle-aged Japanese subjects (2774 men and 1697 women, 50.7 ± 8.5 years). There was a loose correlation between PPG2h and PCG2h (r = 0.327, p < 0.001). The diabetes group (n = 170) showed the highest PPG2h, followed by the IGT group (n = 786) and the NGT group (n = 3414) (p < 0.05). At the cutoff point of 140 mg/dl (7.8 mmol/l) for PPG2h, specificities were 94.9% for IGT plus diabetes and 92.9% for diabetes, but sensitivities were as low as 23.2% for IGT plus diabetes and 44.7% for diabetes. The correlation of PPG2h with PCG2h was stronger in the obese group (BMI ≧ 25 kg/m2) than in the lean group (BMI < 20 kg/m2). We conclude that the correlation between PPG2h and PCG2h was significant but not very tight. In evaluating PPG2h, if the cutoff point of 140 mg/dl (7.8 mmol/l) for PCG2h is extrapolated, the majority of subjects with dysglycemia could be overlooked.