Abstract
Fran May 1984 to June 1995 we performed 112 bone marrow transplants both autologous (34) and allogeneic (78) in children with acute and chronic leukemia and solid tumors. In 19 cases the conditioning regimen included single dose total body irradiation (TBI) (7.5 Gy); in 23 cases fractionated TBI (l2 Gy-2Gy/fr. over 3 days or 10 Gy-3.33 Gy/fr. over 3 days). 70 patients were conditioned without TBI; most of them received busulphan and cyclophosphamide. TBI was delivered by a 10 MV linear accelerator. The inhomogeneity of dose distribution to the lung was compensated by patient arms. No patient developed interstitial pneumonia after TBI; 7/70 patients developed pulmonary complications after busulphan. 3 cases of cataract occured after single dose TBI. In our experience TBI proved to be less dangerous than chemotherapy conditioning regimens; even in single dose TBI we did not observe pulmonary complications.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
