80 - Lipid peroxidation processes in women with primary varicose veins of the pelvic

Abstract

It is assumed that in the progression of primary varicose veins of the pelvic (VVP) in women there is a certain share of the participation of nonspecific reactions. The aim: to study the intensity of processes of lipid peroxidation and antioxidant system in women with primary varicose veins of the pelvic. 167 women of reproductive age were examined - 137 with VVP and 30 - a control group. All patients with VVP were divided into 3 groups according to the stages of the disease. Spectrophotometric and fluorometric methods of investigation were used. It was revealed that the level of primary products of lipid peroxidation, diene conjugates, increased statistically significantly according to the stage of the disease by 1.25 times (in the 1st stage), 1.51 times (in the II stage) and 1.59 times (in the III stage) values. Changes in the content of final TBA-active products showed similar changes-an increase in the mean values for all stages of the disease relative to control (in 1.24, 1.17, and 1.77 times, respectively). Activity of glutathione peroxidase increased in stage 2 of VVP (1.19 times), with the maximum increase in stage III (1.42 times); activity of glutathione-S-transferase increased 1.18 times in the II stage of the disease. The level of catalase activity increased in the I stage of VVP - by 1.18 times and decreased in the III stage - by 1.14 times with respect to the control. The activity of SOD showed similar changes with catalase - in the form of increased activity at the 1st stage (1.35 times higher) and decreased values for II (1.35 times lower) and III (1.65 times lower) for the stages of VVP to the values of control. At progression of primary VVP in women, there is an increase in imbalance in the POL-AOD system.