Abstract

The polysaccharide cell wall is an essential component of fungi that protects the organism from environmental stresses. In medically relevant fungi, such as the mold Aspergillus fumigatus, the cell wall is also the primary site for interaction with host tissues during infection. The absence of cell wall polysaccharides from human cells has made this structure a key target for antifungal development. Over the past several decades, we have expanded our knowledge of the biosynthesis and composition of the fungal cell wall. In this chapter, recent advances in our understanding of Aspergillus fumigatus cell wall polysaccharides are discussed, with an emphasis on molecular and biochemical approaches to understanding the regulation of cell wall biosynthesis.

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