Abstract
8-MOP bath PUVA was compared with 8-MOP oral PUVA in 40 patients with chronic plaque psoriasis to determine the relative efficacy, adverse effects, cost and induced photosensitization. Bath PUVA cleared psoriasis more rapidly than oral PUVA (mean time to clearance (± s.e), 7.1 ± 0.6 weeks vs 10.3 ± 0.9 weeks; P < 0.01), and required fewer treatments (mean number, 20.0 ± 1.7 vs 28.3 ± 2.1; P < 0.01), a lower final UVA dose (mean dose, 2.1 ± 0.2 J/cm2 vs 6.0 ± 0.5 J/cm2; P < 0.001) and a lower total UVA dose (mean dose, 28.3 ± 4.7 J/cm2 vs 110.7 ± 13.8 J/cm2; P < 0.001). Systemic symptoms, chiefly nausea, experienced by two-thirds of patients receiving oral PUVA were absent in the bath PUVA group. The incidence of acute cutaneous adverse effects (pruritus, burning and pain) were similar for both groups. Bath PUVA was more expensive than oral PUVA (cost of a clearing course: £ 69.80 vs £ 30.80). In a study of minimum phototoxic dose determination, bath-water delivery of 8-MOP induced approximately eight time...
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