Abstract
GnRHa are potent inhibitors of LH and FSH release used in treatment of true precocious puberty (TPP). In 8 boys (ages 1y5m - 8y11m)with sexual precocity and advanced bone age we compared the pattern of gonadotropin response to the acute GnRH test (100 ug, iv) and the testosterone levels 30 days after administration of GnRHa(D-Trp6-GnRH 3 mg im or Goserelin 3.6mg sc). LH and FSH were measured by RIA or IFMA, and testosterone by RIA. All patients with TPP, but none with pseudo precocious puberty, had a pubertal LH rise on the acute GnRH test and prepubertal testosterone levels 30 days after GnRHa. However, one patient with a Leydig cell tumor had a partial decrease in testosterone levels. We conclude that prepubertal testosterone levels 30 days after administration of GnRHa is useful to confirm the diagnosis of TPP.
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