Abstract
According to JNC VII, patients with hypertension are patients who clinically have systolic and diastolic blood pressure ≥140 mmHg and ≥90 mmHg, respectively. The aging processes in hypertension are stiffening of the blood vessels and decreasing arterial flexibility. The underlying pathomechanism is oxidative stress due to reactive oxygen species (ROS) elevation. 8-Hydroxy-Deoxyguanosine (8-OHdG) is an oxidized product of DNA repair as a kind of oxidative stress biomarker. This study aimed to analyze urinary 8-OHdG in hypertensive patients and healthy control aged 46-55 years old by involveing 80 participants. Questionnaires and medical records were collected to obtain relevant clinical data. The level of 8-OHdG is measured by the Enzyme-Linked Immunosorbent Assay (ELISA). The results showed that there is no difference in the average urinary level of urinary 8-OHdG of hypertensive patients (1.871 ± 0.689 ng/mL) with the healthy controls (1.743 ± 0.364 ng/mL).
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