Abstract
Publisher Summary This chapter describes the ex vivo measurement of platelet adhesion to polymeric surfaces. Clotting times upon exposure of blood to test materials have been used as a complementary measure of platelet adhesion. It is necessary to distinguish platelet adhesion from blood clotting. The measurement of platelet adhesion is a direct test of surface thrombogenicity. The number of platelets adhered on surfaces varies widely, depending on experimental conditions, such as the species of platelets used, the type of anticoagulant employed, the presence of plasma proteins, and whether in vitro or in vivo assays are used. The transformation of adherent platelets to the spread form and subsequent mural thrombus formation invariably occurs in vivo or ex vivo upon exposure of artificial materials to flowing blood. Environments that allow platelet activation and thrombi formation under in vivo conditions are necessary to accurately evaluate the interaction of blood with biomaterials.
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