8. Efficacy of Renal Denervation on Office Blood Pressure in Resistant Hypertension: a Systematic Review

Abstract

Hypertension almost occurs in about a quarter of the world's population and is still increasing, causing a burden in public health. Renal denervation is one of the strategies to treat resistant hypertension. However, studies on the efficacy of renal denervation in patients with resistant hypertension are still limited and not well known. The purpose of this study was to find out the efficacy of renal denervation in patients with resistant hypertension by office blood pressure measurement. This review was conducted on 10–17 December 2022. Two independent researchers systematically extracted data from several databases, such as PubMed Central (PMC), Science Direct, and PUBMED by using MeSH terminology of keywords renal denervation, hypertension, and safety. The extracted studies were then analyzed and selected according to our inclusion criteria such as studies in the last 5 years, cohort studies, and case-control studies. We excluded systematic reviews, meta-analyses, case series, case reports, studies on pregnant women, children, and animals. Research quality was assessed using Newcastle-Ottawa (NOS). From 5 cohort studies (1605 subjects from various countries), all of them showed renal denervation resulted in better and sustained office blood pressure control on long-term follow up; All studies have proven good quality based on NOS. In conclusion, renal denervation showed efficacy by sustained blood pressure reducing effect in patients with resistant hypertension. However, further study is needed to confirm these findings.