Abstract
The adrenal gland is the primary source of 11-oxygenated 19-carbon steroids, also termed 11-oxyandrogens, which have several roles in human physiology and disease. These include 11β-hydroxyandrostenedione (11OHA4), 11-Ketotestosterone, (downstream metabolite of 11OHA4, mostly produced in peripheral tissues), and its 5α-reduced product, 11-ketodihydrotestosterone (1). The 11-oxyandrogens are bioactive androgens, with potencies equivalent to those of testosterone and dihydrotestosterone, while concentrations of 11-oxyandrogens are elevated in several disorders of androgen excess (2).
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