Abstract

A novel flavone, isolated from the farinose exudate of Primula pulverulenta, was identified as 8,2′-dihydroxyflavone. This is the first naturally occurring flavone, in which ring A is oxygenated only at C-8. The structure was deduced from spectral comparisons with the structurally related flavones: 5,2′-, 3,2′- and 2′,3′-dihydroxyflavone and confirmed by total synthesis. The spectral properties of other flavones oxygenation with a simple pattern are discussed in relation to 8,2′-dihydroxyflavone.

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