7MO Measuring proliferation rates of distinct tumour clones using single-cell DNA sequencing

Abstract

Tumour proliferation rate is a key phenotypic feature of cancer, with higher rates linked to poorer clinical outcomes. Thus far, proliferation rates have been measured using pathological or experimental techniques on bulk tumour samples. However, tumours are heterogeneous compositions of distinct clones with varying levels of fitness. We hypothesise that identifying the most proliferative clones would enable the identification of genomic hallmarks of aggressive clones, or the prediction of their potential phenotype, e.g., metastatic potential.