Abstract
Abstract The coding properties of triplets and polynucleotides containing 7-deazanebularin, a purine nucleoside analogue, have been studied in cell-free ribosomal systems. Polymers containing 7-deazanebularin stimulate ribosomal binding of aminoacyl-tRNA and polypeptide synthesis. The analogue residues show coding ambiguity in the binding tests, since they function as analogues of both adenine and guanine; however, they have so far been found to replace only adenine in directing amino acid incorporation. 7-Deazanebularin substitutes for adenine in all codon positions, showing that the formation of a total of three hydrogen bonds per codon suffices for incorporation of a single amino acid. Triplets containing 7-deazanebularin also stimulate aminoacyl-tRNA binding to ribosomes; in this test system 7-deazanebularin acts best, and perhaps exclusively as an analogue of adenine.
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