犬急性膵炎7例におけるC-反応性蛋白およびα<SUB>1</SUB>-酸性糖蛋白の血漿濃度の変化

Abstract

Plasma concentrations of two acute phase proteins, C-reactive protein (CRP) and α1-acid glycoprotein (α1AG), were measured in seven dogs with acute pancreatitis. All dogs were positive for canine trypsin-like immunoreactivityin plasma at admission to our hospital (Day 0). High plasma concentrations of CRP (>5.0mg/dl) weredetected in four dogs, and high plasma concentrations of α1AG (>500, μg/ml) were found in two dogs. Onedog died on Day 3 with marked increases in plasma concentrations of both CRP and α1AG. Persistently higherconcentrations of both CRP and α1AG were detected in two dogs that required prolonged treatment for pancreatitis.In four dogs with a remarkable recovery, plasma concentrations of either CRP or α1AG returned tonormal ranges in the early stages of treatment. These findings suggest that serial measurements of plasmaconcentrations of both CRP and α1AG were useful markers for evaluating the effects of treatment and prognosisin dogs with acute pancreatitis.