799 THE ANTERIOR CINGULATE GYRUS PLAYS AN IMPORTANT ROLE IN THE CONTROL OF MICTURITION REFLEX IN A RAT MODEL OF PARKINSON'S DISEASE

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research1 Apr 2011799 THE ANTERIOR CINGULATE GYRUS PLAYS AN IMPORTANT ROLE IN THE CONTROL OF MICTURITION REFLEX IN A RAT MODEL OF PARKINSON'S DISEASE Takeya Kitta, Hiroshi Tanaka, Takahiko Mitsui, Yukiko Kanno, Kimihiko Moriya, Katsuya Nonomura, and Naoki Yoshimura Takeya KittaTakeya Kitta Sapporo, Japan More articles by this author , Hiroshi TanakaHiroshi Tanaka Sapporo, Japan More articles by this author , Takahiko MitsuiTakahiko Mitsui Sapporo, Japan More articles by this author , Yukiko KannoYukiko Kanno Sapporo, Japan More articles by this author , Kimihiko MoriyaKimihiko Moriya Sapporo, Japan More articles by this author , Katsuya NonomuraKatsuya Nonomura Sapporo, Japan More articles by this author , and Naoki YoshimuraNaoki Yoshimura Pittsburgh, PA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.617AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Micturition reflex is controlled by a complex hierarchy of the CNS. The pontine micturition center and midbrain periaqueductal gray (PAG) integrates bladder information. The anterior cingulate gyrus (ACG) is also thought to participate in the control of micturition, based on functional brain imaging studies although its functional role is not fully understood. The present study examined dynamic neural activity changes in the ACG and PAG during the micturition reflex induced by pelvic nerve (PLN) stimulation. METHODS Sprague-Dawely rats were divided into PD and sham groups, which were injected with 6-hydroxydopamine and vehicle, respectively, into the substantia nigra. A tungsten electrode was inserted stereotaxically into the ACG and PAG to record field potentials that were evoked by PLN stimulation. The effects of ZM24138 (ZM) (adenosine A2A antagonist) administered intravenously (i.v.) on the PLN evoked field potentials in the PAG and ACG were examined. RESULTS PD rats showed bladder overactivity evidenced by a significant decrease in intercontraction intervals (ICI) compared with sham rats. I.v. administration of ZM increased ICI in both rats with the inhibitory effects being greater in PD vs. sham rats, and also increased the amplitude of the evoked potentials in a dose dependent manner in the ACG of PD rats. However, no significant changes in ACG evoked potentials were found in sham rats. I.v. administration of ZM reduced the amplitude of evoked potentials in PAG of both rats with the inhibitory effects being greater in PD vs. sham rats (figure). CONCLUSIONS In this study, neural activity in the ACG was significantly increased along with suppression of bladder overactivity after ZM administration only in the PD model, suggesting that ACG neurons have an inhibitory role in bladder control. This assumption is supported by human functional brain imaging showing increased responses in the ACG during withholding urine. In addition, reduced ACG activity due to activation of adenosine A2A receptors seems to contribute to bladder overactivity in PD. In contrast, a decrease in PAG activity may lead to inhibition of the micturition reflex. Understanding the roles of CNS nuclei including the ACG in the modulation of micturition could provide further insights into the pathophysiology of OAB. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e321-e322 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takeya Kitta Sapporo, Japan More articles by this author Hiroshi Tanaka Sapporo, Japan More articles by this author Takahiko Mitsui Sapporo, Japan More articles by this author Yukiko Kanno Sapporo, Japan More articles by this author Kimihiko Moriya Sapporo, Japan More articles by this author Katsuya Nonomura Sapporo, Japan More articles by this author Naoki Yoshimura Pittsburgh, PA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...