Abstract

Hematopoietic cell transplantation(HCT) is a potential cure for hematologic malignancy, but is associated with a risk of relapse and death. Dynamic biomarkers to inform treatment decisions after HCT are a major unmet clinical need. We quantified cutaneous leukocyte-endothelial interactions and tested their associations with patient outcomes. METHODS: In this prospective cohort study, patients underwent noninvasive skin videomicroscopy. In videos of dermal microvascular flow, blinded observers counted leukocytes adherent to and rolling along the vessel wall per hour(A&R).

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