Abstract
eclampsia, HELLP syndrome, and normotensive controls. Patients with preeclampsia had significantly higher proteinuria (2.9 / 2.1 grams/24 hours) than either those with HELLP syndrome (0.29 / 0.93 grams/24 hours), or normotensive controls (0.10 / 0.06 grams/24 hours). The degree of podocyturia was higher in patients with preeclampsia (160 / 87 cells/mg creatinine) than in those with either normotensive pregnancies (22 / 20, p 0.02) or HELLP syndrome (21.5 / 8.6, p 0.02); no difference was observed between normotensive vs. HELLP pregnancies (p 0.5). There was a positive correlation between the degree of proteinuria and podocyturia, for the group as a whole (r 0.85, p 0.001). CONCLUSION: Flow cytometry may facilitate the use of podocyturia for both clinical and research purposes. The absence of podocyturia in patients with HELLP syndrome, with either absent or minimal proteinuria, further supports its distinct pathophysiology with respect to preeclampsia.
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