Abstract
Negative outcomes associated with diabetic foot ulcers (DFUs) are devastating, ranging from lower limb amputations to death. One of the major contributing factors of impairment in DFUs healing is inefficient re-epithelialization marked by keratinocyte hyperproliferation and poor migration. Thus, we focused on the role of master-regulators, microRNAs (miRs), in regulation of re-epithelialization in DFUs. We collected tissue samples from DFUs (n=15), control skin samples (n=15), and human acute wounds (n=3) and performed LCM and transcriptomic analyses using Ingenuity Pathway Analysis (IPA).
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