Abstract
Chemoradiation with external beam radiation therapy (EBRT) followed by high dose-rate (HDR) intracavitary brachytherapy (ICBT) is the standard treatment for locally advanced cervical cancer. HDR ICBT for cervical cancer is now well established because of its numerous advantages. Although there are decades of published literature and research on the efficacy of HDR brachytherapy, optimum treatment time, dose, and fractionation still need to be defined. The aim of this study was to assess and compare the local control and toxicities between HDR ICBT with 7.5 Gy per fraction in three fractions (Control Arm) and 9 Gy per fraction in two fractions (Study Arm) after EBRT in treatment of carcinoma cervix.
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