Abstract
Immune-modifying particles (IMPs) composed of biodegradable poly(lactic-co-glycolic acid) (PLGA-IMP) are taken up by circulating inflammatory monocytes via scavenger receptor MARCO and lead them to traffic to the spleen where they undergo apoptosis. PLGA-IMPs has been demonstrated to improve immune-mediated pathology in diverse tissues and inflammatory conditions. Here we report using intravenous PLGA-IMPs for severe acute skin inflammation in a C57/BL6 model of injury induced by topical nitrogen mustard (NM) exposure.
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