Abstract
Glucose metabolism has been demonstrated to be increased in neoplastic tissue, and to reflect the grade of malignancy of human cancer. We studied <i>in vivo</i> glucose metabolism in 22 pts with untreated non-Hodgkin's lymphoma with fluorine-18-fluorodeoxyglucose (FDG) and positron emission tomography (PET). FDG uptake in lymphoma deposits was measured as standardized uptake values (SUVs) of the tracer, and compared with histological classification and proliferative activity. <h3>Results</h3> The median SUV of the lymphomas was 8.5. A high FDG uptake in tumors was associated with high histological degree of malignancy by the Working Formulation (<i>P</i>=0.005) or by the Kiel classification (<i>P</i>=0.003). A high FDG accumulation was also associated with a high S-phase fraction (r=0.786, <i>P</i>=0.002). <h3>Conclusion</h3> FDG PET may find application in assessing the grade of aggressiveness of lymphoma in clinically problematic cases.
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