791. Hyponatremia Incidence and Its Association With Mortality in Patients With Tuberculosis

Abstract

BackgroundIn 2014, 26,000 new cases of tuberculosis were reported in Mexico. TB infection can cause hyponatremia which has a strong association with mortality. The objective of this study was to determine the association of mortality with hyponatremia in patients with tuberculosis infection.MethodsPatients were collected from a 2-year period in the Hospital Dr. Bernardo Sepœlveda in Nuevo Leon, Mexico. Inclusion criteria were patients >18 years of age, with positive tuberculosis tests, and sodium and serum glucose values upon admission.Clinical data from the electronic file were collected and analyzed by descriptive statistics; Student’s t-test and chi-square test were used to compare categorical variables, and Kaplan–Meier to estimate survival curves.ResultsThere were 314 patients with suspected TB, 77 patients were included (Table 1).Table 1. Patient characteristics.CharacteristicsTotal N = 77Normal Sodium N = 23Hyponatremia N = 54 P Age, Mean (SD)41.46 (16.22)41.25 (16.32)41.44 (16.08)Sex Female, %26 (33.7%)8 (34.7%)18 (33.3%)0.90Infection0.63 Pulmonary66 (85.7%)20 (86.9%)46 (85.18%) Pleural6 (7.7%)2 (8.6%)4 (7.4%) Meningeal3 (3.8%)3 (5.5%) Disseminated2 (2.5%)1 (4.3%)1 (1.8%)Serum sodium, mean (SD)131.08 (6.1)Comorbidities Diabetes26 (33.7%)9 (39.1%)17 (31.4%)0.51 Cirrhosis4 (5.1%)4 (7.4%)0.18 HIV14 (18.1%)1 (4.3%)13 (42.5%)0.04Charlson Comorbidity Index, Mean (SD)2.09 (2.38)2.06 (2.38)2.07 (2.39)Drugs Diuretics3 (3.8%)1 (4.3%)2 (3.7%)0.89 ARV5 (6.4%)5 (9.2%)0.13Hospitalized71 (92.2%)22 (95.6%)49 (90.7%)Survival, Mean (SD) Months6.5 (7.15)Mortality, %28 (36.3%)7 (30.4%)21 (38.8%)0.48Mean follow-up was 6.5 ± 7.1 months. Overall mortality rate was 36.3%. Analysis of mortality is presented in Fig 2, and in severe hyponatremia in Figure 3. ConclusionOverall mortality was higher than previously reported, but there was no statistical association between hyponatremia and mortality compared with patients with normal sodium, or by severity. Within the limitations of this study, we must consider that 92% of patients were hospitalized patients at the time of diagnosis, implying that they were patients with complications and may be the reason why both mortality and the incidence of hyponatremia were higher.Disclosures All authors: No reported disclosures.