79 - Signs of oxidative stress parameters in boys of different ethnic groups with exogenous-constitutional obesity

Abstract

Background 25% of adolescents have excessive body weight and 15% of adolescents in the developed countries have obesity. The research of molecular mechanisms of obesity formation in adolescence is topical. Methods 148 boys - Mongoloids (n=75, age – 14.19±1.9) and Russians (n=73, age – 14.03±1.99) were examined. Each ethnic group was divided into subgroups: patients with exogenous-constitutional obesity and control. Spectrophotometric and fluorometric methods were used. Increased levels of primary lipid peroxidation products - diene conjugates (2.48 times), products - TBARs (1.24 times), total antioxidant activity (1.34 times) and decreased activity of glutathione peroxidase (1.49 times) in Mongoloids with obesity compare to the control were registered. Increased levels of TBARs (1.33 times), decreased levels of total antioxidant activity (1.36 times), α-tocopherol (1.45 times), and activity of glutathione peroxidase (1.8 times) in Russians with obesity than in control were revealed. TBARs level was higher (1.25 times) in Mongoloids than in Russians. Conclusion Adolescent boys with exogenous-constitutional obesity experience oxidative stress comparing to adolescent boys with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. The reactivity of the lipid peroxidation system in Mongoloids and Russian boys for obesity is different.