79 A partial hydatidiform mole case with rare karyotype

Abstract

Introduction: A hydatiform mole is a gestational trophoblastic disease, which originates from the placenta and can metastasize. In complete moles, the karyotype is 46,XX 90% of the time and 46,XY 10% of the time. On the other hand, in partial moles, the karyotype is 90% of the time triploid and either 69,XXX or 69,XXY. In developed countries, the incidence of complete moles is approximately 1–3 per 1000 pregnancies and those of the partial moles about 3 per 1000 pregnancies. Methods: Our case was referred us at 17. week of pregnancy because of her high AFP value at routine screening. It was also hyperechogenic fetal bowel, pericardial effusion and placental thickness observed in ultrasonographic examination. At the beginning we put forward molar pregnancy or placental dysplasia in this case and made genetic analysis with amniocentesis. We also investigated TORCH screening but found no specific finding. During these investigation maternal hypertension and proteinuria, growth restriction at fetus was occurred. With these findings we recommended the family to termination and they accepted. Results: After termination we sent fetal material to pathological examination. The result from pathology indicated that the fetal material included partial molar pregnancy with 46 chromosomes. That means it was a rare partial molar pregnancy case with 46 chromosomes. Conclusions: Patial mole is seen with a fetus but complete mole is characterised with molar plasental hypertrphy without fetus. In a partial mole, there typically is the finding of a fetus which may be viable, the presence of amniotic fluid, and the placenta appears to have enlarged, cystic spaces. For partial moles, fertilization takes place between the oocyte and 2 sperm. The zygote is thus triploid. In rare cases the partial hydatidiform mole have also been reported with other karyotypes.