78P Breast cancer hypofractionated radiotherapy and its implications

Abstract

Breast cancer is the most common cancer in female, worldwide. Radiation is an integral part of treatment for local control and even adds to overall survival. Most patients need it, except selective early-stage patients undergoing modified radical mastectomy or elderly patients who were operated & fitting to PRIME II trial criteria. 50 Gy in 25 # is the age-old radiation regimen as given by NSABP trial. In 2008, UK START B trial had shown non-inferiority of 40 Gy in 15 # regimen. Fast Forward trial published in 2020 had proved ultra-hypo-fractionated radiation of 26 Gy in 5 #.