788 Baicalin accelerates wound healing in a murine model of ischemic pressure ulcer lesions

Abstract

Pressure ulcers are a common skin disease that affects the elderly and patients with perceptual or mobility disorders. A pressure ulcer is an ischemic skin necrosis or ulcer that occurs when pressure is applied to a region of the body for an extended period of time, producing poor blood circulation and a lack of oxygen and nutrients. Natural origin pharmaceuticals account for more than half of all modern drugs, and they play an essential role in drug development programs. Baicalin is one of the most important flavonoids in plants, and it is responsible for their pharmacologic effects. This type of natural ingredients provide a wide range of pharmacologic benefits, including anti-inflammatory and anti-tumor properties. The two key processes linked with wound development and effecting the wound healing process with baicalin antioxidant in treating pressure ulcers are oxidative stress and inflammation. However, the effect of baicalin on wound healing in pressure ulcers has not been thoroughly investigated. The wound healing efficacy of baicalin in treating pressure ulcers in a murine pressure ulcer model is investigated in this study. First, the development of 1, 2, 3, 4 stage pressure ulcers after ischemia-reperfusion(I/R) cycle in a murine mouse model. In this model, we investigated the effectiveness of a baicalin in the wound healing of pressure ulcers. We found that baicalin promotes granulation tissue formation, accelerated wound closure, reduced proinflammatory cytokines production and inducing the differentiation of keratinocytes were observed. We expect that this study will contribute to the potential wound therapeutic agent for a pressure ulcer patient.