Abstract
MCC is a rare, immunogenic but aggressive skin cancer. Even after complete resection and radiation relapse rates are high. PD-1/PD-L1 immune checkpoint inhibitors (ICI) showed clinical benefit in locally advanced MCC. ADMEC-O is the first trial to investigate the efficacy/safety of adjuvant PD-1 blockade by ICI in completely resected MCC, i.e. in a situation with no systemic Standard of Care.
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